Inhibition of acetylcholinesterase by O,O-diethyl S-[?-(arylmethylamino)ethyl]thiophosphates and their methyl sulfates

Autor:	N. E. Teplov, L. I. Ginetsinskaya, N. N. Godovikov, I. L. Brik, A. P. Brestkin, M. I. Kabachnik
Rok vydání:	1968
Předmět:	chemistry.chemical_compound Reaction rate constant chemistry Substituent Organic chemistry General Chemistry Sulfate Benzene Ring (chemistry) Medicinal chemistry Acetylcholinesterase
Zdroj:	Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 17:1966-1968
ISSN:	1573-9171 0568-5230
DOI:	10.1007/bf00904993
Popis:	1. The rate constants for the inhibition of acetycholinesterase by O,O-diethyl S-[β-(arylmethylamino)ethyl] thiophosphates and their methyl sulfates were determined. 2. Changes in the inhibiting capacity in the series of O,O-diethyl S-[β-(arylmethylamino)ethyl] thiophosphates toward acetylcholinesterase are associated mainly with the polar effects of the substituents in the benzene ring, whereas the anticholinesterase activity of the corresponding methyl sulfates is little dependent on the substituent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f4ce533ef883fe3f3eb6ec3232eae54 https://doi.org/10.1007/bf00904993 Zobrazit plný text záznamu Full text from SpringerLink