Oxidation of caffeine with hydrogen peroxide catalyzed by metalloporphyrins

Autor:	M. Graça P. M. S. Neves, Artur M. S. Silva, Cláudia Neves, Fernando M. J. Domingues, Filipe A. Almeida Paz, Isabel Santos, José A. S. Cavaleiro, Mário M.Q. Simões
Rok vydání:	2011
Předmět:	Alkaloid Organic Chemistry Inorganic chemistry Substrate (chemistry) chemistry.chemical_element Manganese Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Drug Discovery X-ray crystallography Hydrogen peroxide Caffeine Selectivity
Zdroj:	Tetrahedron Letters. 52:2898-2902
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.03.139
Popis:	The biomimetic oxidation of caffeine with hydrogen peroxide using metalloporphyrins as catalysts, which are known to be good biomimetic models of cytochrome P450 enzymes, is investigated. The two manganese porphyrins tested, chloro[5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]manganese(III), [Mn(TDCPP)Cl], and chloro [5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato]manganese(III), [Mn(TPFPP)Cl], afford high conversions of caffeine for all substrate/catalyst molar ratios. Selectivity was found to be dependent on the catalyst employed, and a new spiro racemic compound is described and fully characterized in the solid state from X-ray diffraction studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f40cb1c546b690064fa7492be37edda https://doi.org/10.1016/j.tetlet.2011.03.139 Zobrazit plný text záznamu Full Text from ScienceDirect