The Role of Hepatic Metabolites of Benzene in Bone Marrow Peroxidase-Mediated Myelo- and Genotoxicity
| Autor: | Michael Schlosser, Robert D. Shurina, John F. Renz, George F. Kalf |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry medicine.disease medicine.disease_cause Pancytopenia Leukemia chemistry.chemical_compound Myelogenous medicine.anatomical_structure chemistry hemic and lymphatic diseases medicine biology.protein Cancer research Arachidonic acid Bone marrow Aplastic anemia business Genotoxicity Peroxidase |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781468458794 |
| DOI: | 10.1007/978-1-4684-5877-0_60 |
| Popis: | Chronic exposure of humans to benzene causes bone marrow depression leading to pancytopenia and aplastic anemia (Goldstein, B.D., 1983). Benzene also causes genotoxic effects such as structural chromosome aberrations and DNA strand breaks (Dean, B.J., 1985) that might be related to the increased incidence of acute myelogenous leukemia that is associated with chronic exposure (Infante, P.F., White, M.C., 1983; Aksoy, M., 1985; Arp, E.W., et al., 1983). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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