Novel pyridazino[4,5-b][1,5]oxazepines and -thiazepines as 5-HT1A receptor ligands

Autor:	E. Horváth, K. Horváth, N. Haider, E. Zára, I. Varga, A. Bakonyi, Péter Mátyus, Ágnes Behr, A. Simay, S. Boros, A. Mezei
Rok vydání:	1997
Předmět:	Bicyclic molecule Tertiary amine Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis In vitro Chain length Drug Discovery Molecular Medicine 5-HT1A receptor Receptor Selectivity Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 7:2857-2862
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(97)10089-0
Popis:	A series of compounds I were synthesized and tested for binding to 5-HT 1A receptors. Substituents and the chain length had a pronounced effect on the recepetor binding affinity. Some componds exhibited activities comparable to buspiron
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3f2a5833756a70c7804157b8d8c55f3e https://doi.org/10.1016/s0960-894x(97)10089-0 Zobrazit plný text záznamu Full Text from ScienceDirect