Interference RNA Intervention in Brain Tumors
| Autor: | Rafal Piestrzeniewicz, Miroslawa Z. Barciszewska, Monika Nowak, Stanisław Nowak, Eliza Wyszko, Jan Barciszewski, Katarzyna Rolle, Zukiel R, Iwona Gawronska |
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| Rok vydání: | 2009 |
| Předmět: |
Chemotherapy
biology business.industry medicine.medical_treatment Brain tumor RNA medicine.disease Platelet membrane glycoprotein nervous system diseases Glioma medicine Cancer research biology.protein Hepatocyte growth factor Epidermal growth factor receptor business neoplasms Glioblastoma medicine.drug |
| Zdroj: | Therapeutic Ribonucleic Acids in Brain Tumors ISBN: 9783642004742 |
| Popis: | Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, such as tenascin-C, an extracellular matrix glycoprotein which contributes to tumor cell adhesion, invasion, migration, and proliferation. Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability, and unpredictable clinical behavior. Disappointing results in the treatment of gliomas with surgery, radiation, and chemotherapy have fueled the search for new treatment modalities. |
| Databáze: | OpenAIRE |
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