Practical Synthesis of 7-Azaserotonin and 7-Azamelatonin
| Autor: | Takahide Nishi, Ren Fukuya, Koji Yamada |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Synlett. 33:2033-2037 |
| ISSN: | 1437-2096 0936-5214 |
| Popis: | A practical method for synthesizing 7-azaserotonin and 7-azamelatonin was developed by using 3-bromo-5-methoxy-1-tosyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-ol as a starting material. This compound is a useful reactant for the formal C3-electrophilic reaction. The lactone derivative obtained by the reaction with Meldrum’s acid was used as a key intermediate, in which the C2 unit was introduced into the 7-azaindole skeleton. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|