New concepts for reconstruction of retinal and pigment epithelial tissues
| Autor: | Paul G. Layer, Astrid Vogel-Höpker, Masasuke Araki |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Expert Review of Ophthalmology. 5:523-543 |
| ISSN: | 1746-9902 1746-9899 |
| DOI: | 10.1586/eop.10.42 |
| Popis: | The rise of stem cell-based regenerative medicine has created great hopes for novel therapies for major blinding diseases. Intensive relevant research is grounded on a deep cellular and molecular knowledge of the complex embryonic development of the neural retina and retinal pigmented epithelium (RPE) from the eye vesicle. This research similarly relies on a long history of transdifferentiation studies, having revealed an innate capacity to regenerate a more or less complete retinal tissue from RPE. To analyze principles of self-organization that govern retinal tissue (re-)construction under normal or regenerative conditions on a ‘cell-by-cell’ basis, the reaggregate approach of dispersed embryonic progenitor cells into retinotypic cellular spheres has been instrumental. Based on this knowledge, a multitude of fascinating studies using embryonic, induced pluripotent, adult stem cells, or permanent cell lines from various species have been carried out over the past two decades, and directed production of h... |
| Databáze: | OpenAIRE |
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