sST2 is a promising biomarker in hypertensive patients undergoing renal denervation
| Autor: | Thomas Weber, Felix Mahfoud, J Grueninger, Uta C. Hoppe, Michael Lichtenauer, Bernhard Wernly, V Paar, Lukas J. Motloch, Mathias C. Brandt, Albert Topf |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | European Heart Journal. 41 |
| ISSN: | 1522-9645 0195-668X |
| Popis: | Introduction Therapy resistant arterial hypertension (raHTN) is a major clinical burden. While therapeutic alternatives are still missing, novel interventional procedures like renal denervation (RD) are still evolving. Indeed, despite discoursing results of the Simplicity HTN-3 trial, new promising results resulted in a revival of this procedure. Therefore, predictors for the success of future interventions would be of great clinical benefit. The novel biomarker sST2 shows promising results for risk stratification of cardiovascular patient. While, sST2 belongs to the IL-1 receptor family, it has an influence on immunologic processes with consequent cardioprotective effects including prevention of myocardial hypertrophy and fibrosis indicating predictive potential in hypertensive heart disease. Nevertheless, clinical implementation of this promising biomarker was not investigated in patients with raHTN undergoing RD. Purpose To investigate a potential clinical relevance of sST2 in patients with raHTN undergoing RD. Methods We evaluated 58 patients with raHTN (age: 63±11 years, systolic blood pressure at baseline: 178±24mmHg) undergoing bilateral RD. If available, serum levels of sST2 were analyzed at baseline as well as at follow-up at one and/or three month. Results While RD was able to decrease blood pressure levels after one month (systolic blood pressure at one month: 158±21mmHg, p Conclusion In patients with raHTN, RD is associated with a significant decrease of sST2 levels, indicating sST2 to be involved in remodeling processes after RD. Furthermore, sST2 levels at baseline might be a potential predictor of intervention success of RD. Further, studies need to investigate the association of sST2 levels and RD. Funding Acknowledgement Type of funding source: None |
| Databáze: | OpenAIRE |
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