Shear Stress-mediated Extracellular Signal-regulated Kinase Activation Is Regulated by Sodium in Endothelial Cells

Autor:	Oren Traub, Mari Ishida, Joan C. Tupper, Bradford C. Berk, Takafumi Ishida
Rok vydání:	1999
Předmět:	Chemistry Sodium channel Sodium chemistry.chemical_element Cell Biology Biochemistry Molecular biology chemistry.chemical_compound Extracellular Tetrodotoxin Biophysics Mechanosensitive channels Molecular Biology Ion transporter Ion channel G alpha subunit
Zdroj:	Journal of Biological Chemistry. 274:20144-20150
ISSN:	0021-9258
DOI:	10.1074/jbc.274.29.20144
Popis:	Fluid shear stress is an important regulator of endothelial cell (EC) function. To determine whether mechanosensitive ion channels participate in the EC response to shear stress, we characterized the role of ion transport in shear stress-mediated extracellular signal-regulated kinase (ERK1/2) stimulation. Replacement of all extracellular Na+ with either N-methyl-D-glucamine or choline chloride increased the ERK1/2 stimulation in response to shear stress by 1.89 +/- 0.1-fold. The Na+ effect was concentration-dependent (maximal effect
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3eff19893315b746088f6ad95e6285ea https://doi.org/10.1074/jbc.274.29.20144 Zobrazit plný text záznamu