Cu(II) complexes of 2-indole thiocarbohydrazones: synthesis, characterization and DNA cleavage studies

Autor:	Anupa A. Kumbhar, Ray J. Butcher, Debamitra Chakravarty, Anita Amate, Shridhar Pawar
Rok vydání:	2021
Předmět:	Indole test Gel electrophoresis Schiff base General Chemistry Triclinic crystal system Fluorescence spectroscopy law.invention chemistry.chemical_compound chemistry law Polymer chemistry Proton NMR Electron paramagnetic resonance DNA
Zdroj:	Journal of Chemical Sciences. 133
ISSN:	0973-7103 0974-3626
Popis:	Two Schiff base ligands FT1 and FT2 and their Cu(II) complexes were synthesized and characterized by 1H NMR, ESI-MS, IR, UV-Visible, Fluorescence spectroscopy, EPR and single-crystal X-ray diffraction studies. FT1 crystallizes in the triclinic system while FT2 in the orthorhombic. The DNA cleavage activity of Cu(II) complexes was studied using plasmid pBR322 DNA by gel electrophoresis. All compounds cleave DNA on photoirradiation by oxidative mechanism. Two Schiff base ligands FT1 and FT2 and their Cu(II) complexes were synthesized and characterized by 1H NMR, ESI-MS, IR, UV-Visible, Fluorescence spectroscopy, EPR and single-crystal X-ray diffraction studies. Both the Cu(II) complexes of indole thiocarbohydrazones are shown to cleave plasmid pBR322 DNA by oxidative mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3efa2b205d47aaf43d75e7beab84c4e5 https://doi.org/10.1007/s12039-021-01962-x Zobrazit plný text záznamu Full text from SpringerLink