An Efficient and Impurity-Free Process for Telmisartan: An Antihypertensive Drug

Autor:	Kikkuru Srirami Reddy, Vijayavitthal T. Mathad, Naveenkumar Kolla, Yerremilli Anjaneyulu, Sundaram Venkatraman, and Apurba Bhattacharya, Chinta Raveendra Reddy, Neti Srinivasan
Rok vydání:	2006
Předmět:	Chemistry Process development medicine.drug_class Organic Chemistry medicine Physical and Theoretical Chemistry Telmisartan Pharmacology Antihypertensive drug Combinatorial chemistry medicine.drug
Zdroj:	Organic Process Research & Development. 11:81-85
ISSN:	1520-586X 1083-6160
Popis:	Telmisartan (1), a substituted dibenzimidazole derivative, is an antihypertensive drug, essentially used to control blood pressure. An improved, cost-effective, and impurity-free process for telmisartan (1) suitable for large-scale production is described here by addressing various process development issues. The overall yield obtained from this newly developed process is around 50% (over five steps) compared to the literature reported process (21%, over eight steps).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3ee56094418fe999e7a09c0fc91cd56e https://doi.org/10.1021/op060200g Zobrazit plný text záznamu