Microbiome of human skin - its immunohomeostatic role and the role in pathogenesis of skin diseases

Autor:	D D Petrunin
Rok vydání:	2018
Předmět:	Pathogenesis business.industry Secondary infection medicine Treatment options Topical treatment Human skin General Medicine Atopic dermatitis Microbiome medicine.disease Bioinformatics business
Zdroj:	Russian Journal of Allergy. 15:63-81
ISSN:	2686-682X 1810-8830
DOI:	10.36691/rja190
Popis:	In the last decade new methods of metagenomic analysis allowed to obtain important data regarding the microbiome of human skin. The problem of colonization and secondary infection by pathogenic microbes is of special importance for allergic dermatoses that require topical immunosuppressive therapy. One of treatment options in this case could be topical multicomponent drugs that allow successful treatment of infectious complications of inflammatory dermatoses. But there are still a lot of blanks regarding both fundamental questions regarding human skin microbiome and practice aspects of treatment of skin diseases where it plays a pathogenetic role. This literature review systematizes and structures the accumulated data regarding the composition and the role of human skin microbiome in normal conditions and in various skin diseases as well as summarizes clinical data of use of combinational topical glucocorticosteroid drugs. Furthermore, some algorithms concerning the choice and optimization of topical treatment of secondary infected dermatoses are outlined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3edfa0bc3c55b62ea1957af410ae95c9 https://doi.org/10.36691/rja190 Zobrazit plný text záznamu