Catalyst-Free, Visible-Light Promoted One-Pot Synthesis of Spirooxindole-Pyran Derivatives in Aqueous Ethyl Lactate
| Autor: | Mo Zhang, Qiu-Yang Fu, Zhan-Hui Zhang, Ge Gao, Yin-su Wu, He-Ye He, Ying Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
Aqueous solution
010405 organic chemistry Renewable Energy Sustainability and the Environment General Chemical Engineering One-pot synthesis General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Pyran Dimedone Yield (chemistry) Environmental Chemistry Organic chemistry Ethyl lactate Malononitrile |
| Zdroj: | ACS Sustainable Chemistry & Engineering. 5:6175-6182 |
| ISSN: | 2168-0485 |
| DOI: | 10.1021/acssuschemeng.7b01102 |
| Popis: | A highly efficient, eco-friendly protocol has been developed for synthesis of spirooxindole-pyran derivatives via one-pot, three-component reaction of isatins, malononitrile, and enolizable C–H activated compounds (2-hydroxynaphthalene-1,4-dione, 4-hydroxycoumarine and dimedone) under visible-light irradiation in water-ethyl lactate at room temperature. The reported approach shows significant advantages such as a high yield, mild and clean reaction conditions, the application of clean visible light as a source of energy, the absence of catalyst, the use of ethyl lactate/water as an environmentally friendly solvent, a one-pot multicomponent reaction at room temperature, no chromatographic separation, and applicability for large-scale synthesis. |
| Databáze: | OpenAIRE |
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