Lifestyle for Brain Health (LIBRA): a new model for dementia prevention
| Autor: | Frans R.J. Verhey, Olga J. G. Schiepers, Marjan van den Akker, Catherine A. O'Donnell, Kate Irving, Martin P.J. van Boxtel, Stephanie J.B. Vos, Sebastian Köhler, Kay Deckers, Marjolein E. de Vugt |
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| Rok vydání: | 2017 |
| Předmět: |
Gerontology
education.field_of_study Population Cognition medicine.disease Hazard 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Ageing Cognitive change medicine Dementia 030212 general & internal medicine Geriatrics and Gerontology Cognitive decline Psychology education Cognitive impairment 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Geriatric Psychiatry. 33:167-175 |
| ISSN: | 0885-6230 |
| DOI: | 10.1002/gps.4700 |
| Popis: | Objective Modifiable risk factors for dementia were recently identified and compiled in a systematic review. The ‘Lifestyle for Brain Health’ (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16 years. Methods Lifestyle for Brain Health was calculated at baseline for 949 participants aged 50–81 years from the Maastricht Ageing Study. The predictive value of LIBRA for incident dementia and cognitive impairment was examined by using Cox proportional hazard models and by testing its relation with cognitive decline. Results Lifestyle for Brain Health predicted future risk of dementia, as well as risk of cognitive impairment. A one-point increase in LIBRA score related to 19% higher risk for dementia and 9% higher risk for cognitive impairment. LIBRA predicted rate of decline in processing speed, but not memory or executive functioning. Conclusions Lifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors. Copyright © 2017 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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