Asymmetric Formal Synthesis of Trichodermamides B and C
Autor: | Violeta Petrova, Masayoshi Arai, Hayato Saito, Atsushi Kimishima |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Synlett. 32:1865-1868 |
ISSN: | 1437-2096 0936-5214 |
Popis: | An asymmetric formal synthesis of trichodermamides B and C was achieved in 15 steps based on a tyrosine ester chiral-pool approach. Key features of this synthesis include stereoselective construction of a cis-1,2-oxazadecaline core by an acid-mediated tandem deprotection–intramolecular oxy-Michael reaction, oxime ether formation via an N-bromination–elimination sequence, and diene construction by a palladium-catalyzed demonomethylcarbonation. |
Databáze: | OpenAIRE |
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