Expression of Select Function Associated Antigens During Pregnancy

Autor:	Daniel V. Landers, Bonnie A. Coyne, William R. Crombleholme, Janis P. Smith
Rok vydání:	1995
Předmět:	biology business.industry medicine.drug_class CD3 T-cell receptor Obstetrics and Gynecology Monoclonal antibody Peripheral blood mononuclear cell Immune system Antigen Pediatrics Perinatology and Child Health Immunology biology.protein Medicine IL-2 receptor Antibody business
Zdroj:	Journal of Maternal-Fetal and Neonatal Medicine. 4:115-119
ISSN:	1476-4954 1476-7058
DOI:	10.3109/14767059509017310
Popis:	Pregnancy has long been associated with alterations in phenotypic and functional characteristics of the immune response. We studied a variety of T lymphocyte subsets defined by specific antigen expression during pregnancy using a fluorescence activated cell sorter (FACS) and fluorescein conjugated monoclonal antibodies. Specifically, we performed a cross-sectional analysis of the peripheral blood mononuclear cells from 20 women in the first trimester, 20 women in the second trimester, 26 women in the third trimester and 20 women at the time of delivery. We analyzed for antibody staining of CD3, CD4, CD25 (IL-2 receptor), T cell receptor (beta chain), T cell receptor (delta chain) and two color staining for CD3/CD18 (LFA-1), CD3/CD56 and CD4/CD45R. There was little change in the numbers of cells staining for these antibodies through the three trimesters and at delivery with the exception of T lymphocytes bearing the LFA-1 antigen which were significantly less in the first trimester (P < 0.05). These data s...
Databáze:	OpenAIRE
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