Neuromorphological Aspects of the GABAergic Hypothesis of the Pathogenesis of Schizophrenia
| Autor: | V. M. Vostrikov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
business.industry General Neuroscience Schizophrenia (object-oriented programming) Dopaminergic Serotonergic behavioral disciplines and activities Pathogenesis 03 medical and health sciences Glutamatergic 030104 developmental biology 0302 clinical medicine Neurochemical Neuroimaging mental disorders Medicine GABAergic business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience and Behavioral Physiology. 50:663-668 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-020-00952-9 |
| Popis: | The scientific literature contains several hypotheses for the pathogenesis of schizophrenia. The most widespread hypotheses for schizophrenia are the dopaminergic, serotoninergic, and glutamatergic hypotheses. There is also the suggestion that other neurochemical systems are involved in the pathogenesis of schizophrenia, particularly the GABAergic. This review considers published data on derangements of GABAergic interneurons in schizophrenia, taking account of data on post-mortem, neuroimaging, molecular-genetic, and electrophysiological research. A hypothesis for the pathogenesis of schizophrenia based on impairments to the myelination of GABAergic interneurons is proposed, these impairments leading to decreases in the numbers of intra- and interhemisphere coherent connections and the appearance of symptoms of the disease. |
| Databáze: | OpenAIRE |
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