Is the modulatory effect of pregnancy in multiple sclerosis associated with changes in blood apoptotic molecules?
| Autor: | Sanna Rinta, Irina Elovaara, Laura Airas |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pregnancy business.industry Multiple sclerosis medicine.medical_treatment General Medicine medicine.disease Fas ligand Immune system Endocrinology Cytokine Neurology Downregulation and upregulation Internal medicine Immunology medicine Tumor necrosis factor alpha Macrophage migration inhibitory factor Neurology (clinical) business |
| Zdroj: | Acta Neurologica Scandinavica. 122:168-174 |
| ISSN: | 0001-6314 |
| DOI: | 10.1111/j.1600-0404.2009.01301.x |
| Popis: | Rinta S, Airas L, Elovaara I. Is the modulatory effect of pregnancy in multiple sclerosis associated with changes in blood apoptotic molecules? Acta Neurol Scand: 2010: 122: 168–174. © 2010 John Wiley & Sons A/S. Objective – We examined whether the modulatory effect of pregnancy on multiple sclerosis (MS) is associated with changes in the apoptotic molecules in sera. Subjects and methods – The serum levels of tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), sFas, Fas ligand (sFasL) and macrophage migration inhibitory factor were analyzed from 19 MS patients and 14 controls during late pregnancy and post-partum. The obtained results were related to disease activity and the progression of MS. Results – Disease activity decreased during pregnancy. The levels of sTRAIL and sFasL increased from late pregnancy to post-partum situation in both MS patients and controls, but in MS patients the changes in the levels of sTRAIL from late pregnancy to post-partum were smaller than in controls. Conclusions – Post-partum upregulation of TRAIL and FasL seems to be caused by physiologic reactivation of the mother’s immune system after pregnancy. An increased risk of relapses in MS post-partum may be associated with changes in the immunomodulatory potential of these apoptotic molecules. |
| Databáze: | OpenAIRE |
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