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A series of structurally novel 1,3,4-oxadiazole thioether derivatives ( 6a ― 6z ) containing a 6-fluoroquinazolinylpiperidinyl moiety were designed and synthesized using pharmacophore hybrid approach, and their structures were fully characterized by 1 H NMR, 13 C NMR and HRMS spectra. Among them, the structure of compound 6d was further corroborated via single-crystal X-ray diffraction analysis. In vitro antibacterial bioassays showed that compounds 6a , 6 g , 6 u and 6v possessed EC 50 values of 30.4, 30.6, 27.5 and 26.0 μg / mL against phytopathogenic bacterium Xanthomonas oryzae pv . oryzae , respectively, which were significantly superior to that of commercially-available bactericide Bismerthiazol (85.1 μg / mL). Moreover, in vitro antifungal bioassays indicated that seven compounds demonstrated broad-spectrum fungicidal acitivties against six types of phytopathogenic fungi at 50 μg / mL. The present work showed the potential of 1,3,4-oxadiazole thioether derivatives carrying a 6-fluoroquinazolinylpiperidinyl moiety as effective antimicrobial agents for crop protection, deserving further investigations in the future. |
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