Does lobular carcinoma in situ (LCIS) affect biology of future breast cancer? Surveillance Epidemiology and End Results (SEER) database review

Autor:	Anteneh Tesfaye, David Eilender, Mohammad Mozayen, Ioana Morariu
Rok vydání:	2012
Předmět:	Oncology Cancer Research medicine.medical_specialty business.industry Lobular carcinoma Seer database medicine.disease Breast cancer Internal medicine Lobular carcinoma in situ (LCIS) medicine Surveillance Epidemiology and End Results Risk factor business
Zdroj:	Journal of Clinical Oncology. 30:37-37
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2012.30.27_suppl.37
Popis:	37 Background: Lobular carcinoma in situ (LCIS) is a recognized risk factor of breast cancer. Data evaluating the behavior of breast cancer arising after LCIS is lacking. Our study compared the characteristics of breast cancer arising after LCIS with the breast cancer arising de novo. Methods: From the 1973-2009 SEER database, women with breast cancer who were diagnosed and treated between 1990 and 2009 were abstracted. Patients were divided to group A: breast cancer after LCIS, group B: de novo breast cancer. Age, ethnicity, staging, tumor size, grade and hormone receptor status were reviewed. Data were analyzed using chi square, Kaplan-Meier, Life table, and Cox proportional hazard model. Results: Patients with LCIS were 7,258 with 547 (7.5%) developing breast cancer subsequently. The mean (SD) time to develop breast cancer after LCIS was 68 (2.14) months. Of the total 557,309 patients with breast cancer, group A had 547 patients and group B had 556,762 patients. The median tumor size was 1.3 and 1.8 cm in groups A and B respectively (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3eba981241d4f848239399c70869369e https://doi.org/10.1200/jco.2012.30.27_suppl.37 Zobrazit plný text záznamu