Semaphorin 3A in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients
| Autor: | Nancy A Mohamed, Mohamed Ezz Eldin Mowafy, Wessam S Ibrahim, Radwa M. El-Khouly |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Proteinuria Systemic lupus business.industry Group ii General Medicine Significant negative correlation Age and sex medicine.disease Gastroenterology Semaphorin immune system diseases Internal medicine Rheumatoid arthritis Immunology medicine Extra-Articular medicine.symptom skin and connective tissue diseases business |
| Zdroj: | Rheumatology: Current Research. |
| ISSN: | 2161-1149 |
| DOI: | 10.4172/2161-1149.1000207 |
| Popis: | The aim of this study is to evaluate Semaphorin 3A level in rheumatoid arthritis and systemic lupus and its correlation with clinical, laboratory markers of disease activity and extra articular manifestations. Fifteen (RA) patients GROUP I and fifteen (SLE) patients GROUP II with age and sex matched fifteen healthy volunteers who served as controls GROUP III were studied. Disease activity score was used to assess disease activity in RA and SLE patients, MHAQ, RF and ANTICCP were measured for RA patients. Also ANA, Anti-dsDNA was measured for SLE patients. The serum level of semaphoring 3A was assessed by (ELISA) technique for the RA, SLE patients and control group. Group II SLE patients had significant decrease in serum level of semaphoring 3A versus group I RA patients and control group also there was significant decrease in semaphorine 3 A level in group I in RA in comparison with control group. There were significant negative correlation between Semaphorin 3A and disease duration, laboratory markers of disease activity (ESR1st h,CRP) and grades of disease activity (DAS28). There were significant negative correlation between Semaphorin 3A and SLEDAI score, ANA, anti-dsDNA and renal affection (proteinuria) in SLE patients. |
| Databáze: | OpenAIRE |
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