The German multi-centre study on smoking-related behavior-description of a population-based case-control study
| Autor: | Michael Wagner, Jürgen Brinkmeyer, Amalia Diaz-Lacava, Daniela A. Holler, Thomas F. Wienker, Svenja Schulze-Rauschenbach, Christoph von der Goltz, Gerhard Gründer, Katja N. Spreckelmeyer, Norbert Thürauf, Annette Lindenberg, Falk Kiefer, Walter de Millas, Georg Winterer, Norbert Dahmen, Marion Clepce, Jürgen Gallinat, Arian Mobascher, Michael Steffens |
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| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
education.field_of_study medicine.medical_specialty business.industry media_common.quotation_subject Population Case-control study Medicine (miscellaneous) Social environment language.human_language German Psychiatry and Mental health language Medicine Personality Risk factor education business Risk assessment Psychiatry Psychosocial media_common Demography |
| Zdroj: | Addiction Biology. 16:638-653 |
| ISSN: | 1355-6215 |
| DOI: | 10.1111/j.1369-1600.2011.00322.x |
| Popis: | Tobacco smoking is a major risk factor for most of the diseases leading in mortality. Nicotine dependence (ND), which sustains regular smoking, is now acknowledged to be under substantial genetic control with some environmental contribution. At present, however, genetic studies on ND are mostly conducted in populations that have been poorly characterized with regard to ND-related phenotypes for the simple reason that the respective populations were not primarily collected to study ND. The German multi-centre study 'Genetics of Nicotine Dependence and Neurobiological Phenotypes', which is funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) as part of the Priority Program (Schwerpunktprogramm) SPP1226: 'Nicotine-Molecular and Physiological Effects in CNS', was intended to overcome some of these inherent problems of current genetic studies of ND. The multi-centre study is a population-based case-control study of smokers and never-smokers (n = 2396). The study was unique worldwide because it was the first large-scale genetic study specifically addressing ND with the collection of a wide range of environmental, psychosocial and neurobiological phenotypes. Study design and major population characteristics with emphasis on risk prediction of smoking status were presented in this paper. |
| Databáze: | OpenAIRE |
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