Recommendations of the Austrian Working Group on Lung Pathology and Oncology for predictive molecular and immunohistochemical testing in non-small cell lung cancer
| Autor: | Georg Hutarew, William Sterlacci, Patricia Grabher, Ulrike Setinek, Gerald Webersinke, Klaus Kirchbacher, Michael Vesely, Helmut Popper, Wolfgang Hilbe, Elvira Stacher, Rainer Kolb, Maximilian Hochmair, Wolfgang Hulla, Hans Maier, Tamara Hernler, Leonhard Müllauer, Ferdinand Ploner, Ulrike Gruber-Moesenbacher, Robert Pirker |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty biology business.industry medicine.medical_treatment Hematology medicine.disease Targeted therapy Internal medicine medicine biology.protein ROS1 Adenocarcinoma Immunohistochemistry Pulmonary pathology Epidermal growth factor receptor Lung cancer business Tyrosine kinase |
| Zdroj: | memo - Magazine of European Medical Oncology. 6:83-91 |
| ISSN: | 1865-5076 1865-5041 |
| DOI: | 10.1007/s12254-013-0087-7 |
| Popis: | The introduction of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) for non-small cell lung cancer (NSCLC) with activating mutations of the EGFR has opened a new area of lung cancer treatment strategies and led to an enthusiastic search for additional mutations. Since then, numerous driver mutations such as EML4-ALK and ROS1 have been detected and specific treatment options have already been developed. However, molecular tests have to follow specific rules if applied in daily practice. The Austrian Working Group on Pulmonary Pathology and Oncology (AWGPPO) is presenting an updated version of their previous recommendation published in 2011. Several practical questions raised during the last 2 years will be addressed, such as reflex testing, selection of tissues, order of molecular tests, and the issue of resistance mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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