Effects of coagulation Factor VII polymorphisms on the coronary artery disease in Japanese
| Autor: | Kyosuke Takeshita, Miyoshi Ohno, Takahisa Kondo, Shigeo Iino, Hidehiko Saito, Yasuya Inden, Makoto Hirai, Keiko Shimokata |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Factor VII business.industry Hematology Odds ratio medicine.disease Gastroenterology Surgery Coronary artery disease Coronary arteries chemistry.chemical_compound medicine.anatomical_structure chemistry Polymorphism (computer science) Internal medicine medicine cardiovascular diseases Myocardial infarction Allele Risk factor business |
| Zdroj: | Thrombosis Research. 105:493-498 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/s0049-3848(02)00067-1 |
| Popis: | We investigated the relationships among Factor VII coagulant activity (FVIIc), genetic polymorphisms of Factor VII (FVII) and coronary artery disease (CAD) in 380 unrelated Japanese individuals (mean 64 years) who underwent coronary angiography and whose cholesterol levels were within normal range. CAD subjects were defined as those in whom one of the three major coronary arteries showed >50% narrowing after nitroglycerin administration. FVIIc was measured and the following polymorphisms of FVII were determined: R353Q polymorphism (M1, M2 alleles), −323 0/10 bp polymorphism (0, 10 alleles), hypervariable region 4 of intron 7 (HVR4; H5, H6, H7 alleles). FVIIc was slightly lower in M1M2/M2M2 than M1M1 (89.5±8.9%, 93.4±17.8%). Those with M2 and/or 10 allele have less chance of developing CAD (M2: OR 0.36, 95% CI 0.18–0.69, 10: OR 0.50, 95% CI 0.26–0.97). However, both alleles did not associate with myocardial infarction (MI). HVR4 was unrelated with CAD, nor with MI. In conclusion, M2 and/or 10 allele has protective effects on the developing CAD in individuals with a normal cholesterol level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect