Carbohydrate - lipid conjugates for targeted drug and gene delivery

Autor:	Saifuddin Sheikh, Ateeq Ahmad, Shoukath M. Ali, Imran Ahmad, Moghis U. Ahmad, Paul Chen
Rok vydání:	2015
Předmět:	Drug Liposome Chemistry media_common.quotation_subject Pharmacology Gene delivery General Biochemistry Genetics and Molecular Biology Glycolipid Targeted drug delivery Biochemistry Control and Systems Engineering Drug delivery Macrophage Drug carrier Food Science media_common
Zdroj:	Lipid Technology. 27:223-226
ISSN:	0956-666X
Popis:	The role of macrophages in the uptake and processing of liposomes evident from the increased deposition of liposomal content in cells. It has been reported that macrophages may serve as a secondary drug carrier for the delivery of liposomal drugs. The uptake of liposomal content by macrophages can be promoted by incorporation of ligands capable of interacting with macrophage surface receptors. Therefore, carbohydrate-based molecules for targeted drug and gene delivery must be developed for rational therapy. In this article, we report the synthesis of glycolipid conjugates for applications in liposomal drug delivery systems and for targeting drugs and genes to receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3ea34256a88c9b901d788bc0c8a985c8 https://doi.org/10.1002/lite.201500047 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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