Synthesis and Antitumor Activity ofN-Acetylmuramyl-L-alanyl-D-isoglutamine 6-Phosphate and Its Lipophilic Derivatives

Autor:	Shoichi Kusumoto, Masahiro Imoto, Shigeki Kageyama, Kensuke Matsumoto, Shinjiro Hashimoto, Tetsuo Shiba, Morihiro Kohno, Akiko Tohgo
Rok vydání:	1986
Předmět:	carbohydrates (lipids) Antitumor activity chemistry.chemical_compound Dipeptide chemistry Stereochemistry N-Acetylmuramyl-L-Alanyl-D-Isoglutamine Aminoglycoside Biological activity General Chemistry Phosphate Glycopeptide Muramyl dipeptide
Zdroj:	Bulletin of the Chemical Society of Japan. 59:3207-3212
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.59.3207
Popis:	6-Phosphate of N-acetylmuramyl-L-alanyl-D-isoglutamine and its lipophilic derivatives, i.e., 6-(octadecyl hydrogenphosphate) and 6-(2-docosyltetracosyl hydrogenphosphate) were synthesized after the structural feature of mycobacterial cell walls for the purpose to modify and possibly to enhance the immunostimulating activity of the muramyl dipeptide which is the minimum requisite for the activity. As expected, the latter more lipophilic phosphate showed a high activity in a tumor regression test.
Databáze:	OpenAIRE
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