Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Autor:	Zacharia S. Cheruvallath, Brett Turney, Hans Gaus, Vasulinga T. Ravikumar, Achim H. Krotz, Anthony N. Scozzari, and Douglas L. Cole, Daniel C. Capaldi, Stephen R. Craig, Recaldo L. Carty, Patrick Wheeler, Max N. Moore
Rok vydání:	1999
Předmět:	Phenylacetyl disulfide Active ingredient Chemistry Reagent Organic Chemistry Antisense oligonucleotides Organic chemistry Physical and Theoretical Chemistry Combinatorial chemistry
Zdroj:	Organic Process Research & Development. 4:199-204
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op990077b
Popis:	It is demonstrated that phosphorothioate oligodeoxyribonucleotides can be synthesized on scales from 1 μmol to 150 mmol using phenylacetyl disulfide (PADS) as an efficient and economical replacemen...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3e970352d578d58f7c57c74c0d4f4474 https://doi.org/10.1021/op990077b Zobrazit plný text záznamu