| Autor: |
Roger W. Roeske, Tanya Hrinyo-Pavlina, N. C. Chaturvedi, Maria Kowalczuk |
| Rok vydání: |
1987 |
| Předmět: |
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| Zdroj: |
LHRH and Its Analogs ISBN: 9789401079495 |
| DOI: |
10.1007/978-94-009-3229-6_2 |
| Popis: |
Many synthetic antagonists of LHRH having pituitary receptor binding affinities of 10 to 20 times that of LHRH itself have been made. Generally, the best antagonists have an ED50 of about one microgram per animal in the rat antiovulatory assay. Most of these highly effective antagonists have a D-arginine residue in position 6 which, with the L-arginine8 of the native molecule and with a hydrophobic cluster of residues in the N-terminal part of the molecule, appears to be a potent canbination for the release of histamine from mast cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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