Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine

Autor:	András Keglevich, Áron Szigetvári, László Hazai, Miklós Dékány, Szantay Csaba, Péter Keglevich
Rok vydání:	2019
Předmět:	chemistry.chemical_compound chemistry 010405 organic chemistry Organic Chemistry Triphenylphosphine 010402 general chemistry 01 natural sciences Combinatorial chemistry In vitro 0104 chemical sciences Vindoline
Zdroj:	Current Organic Chemistry. 23:852-858
ISSN:	1385-2728
DOI:	10.2174/1385272823666190524083236
Popis:	An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives were coupled with triphenylphosphine, to afford the expected phosphonium salts. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3e88087aecf9f32e5d386c9b041ebdff https://doi.org/10.2174/1385272823666190524083236 Zobrazit plný text záznamu