The utility of 82Rb PET for myocardial viability assessment: Comparison with perfusion-metabolism 82Rb-18F-FDG PET
| Autor: | Alexis Poitrasson-Rivière, Richard L. Weinberg, James R. Corbett, Benjamin C. Lee, Edward P. Ficaro, Keri M. Hiller, Venkatesh L. Murthy, Jonathan B. Moody |
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| Rok vydání: | 2019 |
| Předmět: |
Fluorodeoxyglucose
Hibernating myocardium Ischemic cardiomyopathy business.industry medicine.medical_treatment Ischemia Blood flow 030204 cardiovascular system & hematology medicine.disease Revascularization 030218 nuclear medicine & medical imaging Rubidium-82 03 medical and health sciences 0302 clinical medicine medicine Radiology Nuclear Medicine and imaging medicine.symptom Cardiology and Cardiovascular Medicine Nuclear medicine business Perfusion medicine.drug |
| Zdroj: | Journal of Nuclear Cardiology. 26:374-386 |
| ISSN: | 1532-6551 1071-3581 |
| DOI: | 10.1007/s12350-019-01615-0 |
| Popis: | 82Rb kinetics may distinguish scar from viable but dysfunctional (hibernating) myocardium. We sought to define the relationship between 82Rb kinetics and myocardial viability compared with conventional 82Rb and 18F-fluorodeoxyglucose (FDG) perfusion-metabolism PET imaging. Consecutive patients (N = 120) referred for evaluation of myocardial viability prior to revascularization and normal volunteers (N = 37) were reviewed. Dynamic 82Rb 3D PET data were acquired at rest. 18F-FDG 3D PET data were acquired after metabolic preparation using a standardized hyperinsulinemic-euglycemic clamp. 82Rb kinetic parameters K1, k2, and partition coefficient (KP) were estimated by compartmental modeling Segmental 82Rb k2 and KP differed significantly between scarred and hibernating segments identified by Rb-FDG perfusion-metabolism (k2, 0.42 ± 0.25 vs. 0.22 ± 0.09 min−1; P |
| Databáze: | OpenAIRE |
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