| Autor: |
Yunda Hong, Yongzhi Zheng, Yan Huang, Jiazheng Li, Jianda Hu, Jingjing Wen, Yi Chen, Yanxin Chen |
| Rok vydání: |
2021 |
| Předmět: |
|
| Popis: |
Prognosis of acute lymphoblastic leukemia (ALL) in adults is inferior to children. Hence, ALL is still a challenging disease to be cured in adult population. Aberrant genetic alterations have been observed previously in ALL, while the patterns of differential gene alteration have not much been comprehensively determined in the adult and pediatric ALL on a genome-wide scale. This study was attempted to investigate the biological differences in genomic profiling between the adults and children with ALL, and the relationship between the genomic heterogeneity and prognosis. The results showed the similar common mutation types in two populations but the increased prevalence of genetic alterations in adult ALL. The median number of detected gene mutations was 17 (range: 1–53) per sample in adult ALL and 4.5 (range: 1–19) in pediatric ALL(P2 = 0.5853, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
