| Popis: |
The therapeutic use of extraordinary virtues of algae in healthcare is very ancient and has evolved throughout the history of humanity. However, low or high doses and/or prolonged administration of algae-derived biologically active substances may trigger adverse or even harmful effects such as hemolytic properties. In this study, hemolytic activities of the brown algae Cystoseira myriophylloides (F/Sargassaceae) from El Jadida coast (Moroccan Atlantic coast) on human erythrocyte were investigated. The toxicity of chloroform-methanolic, methanolic, chloroformic, isoprpanolic and butanolic extracts and fractions derived from Cystoseira myriophylloides on human erythrocytes was measured by in vitro hemolytic assay. The results obtained show variable cytotoxicity of C. myriophyloides against the red blood cells. Indeed, the crude extract has a fairly high hemolytic activity that is very marked when the erythrocytes are incubated in the presence of the chloroformic extract. However, the cytotoxic activity is greatly increased in the presence of the butanolic fraction derived by partitioning of the isopropanolic extract. Moreover, the hemolysis activity is dose-dependent and depending on the evolution of incubation time. Thus, these results show that the majority of extracts and fractions of brown macroalgae Cystoseira myriophylloides manifest hemolytic activity. |
