OHP-017 Ability of infusion devices to deliver the expected volume of antineoplastic drug in solution: anin vitroassessment: Abstract OHP-017 Table 1
| Autor: | Pascal Odou, Nicolas Simon, M Pinturaud, M Lebecque, M Vasseur, Bertrand Décaudin, JF Legrand, Christine Barthélémy |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
medicine.medical_specialty Chromatography medicine.diagnostic_test business.industry Antineoplastic drug media_common.quotation_subject Drug administration Drug substitute Surgery Volume (thermodynamics) Pharmacokinetics Therapeutic drug monitoring Antineoplastic Drugs medicine General Pharmacology Toxicology and Pharmaceutics business media_common |
| Zdroj: | European Journal of Hospital Pharmacy. 22:A193.1-A193 |
| ISSN: | 2047-9964 2047-9956 |
| Popis: | Background For several years, many infusion systems have been marketed for the administration of antineoplastic drugs (AD). Purpose To compare the ability of these devices to deliver the expected volume of antineoplastic drug in solution. Material and methods Seven infusion devices were assessed (see table 1) by simulated infusions with a radiotracer ( 99m TcO 4 − ) as drug substitute. The same activity (370 MBq) was diluted in 250 mL 0.9% NaCl bags. The evolution of the drug concentration at the egress of the infusion system was recorded continuously with a sodium iodine crystal detector. The area-under-curve of drug concentration according to time of both administration (AUC adm ) and rinsing (AUC rin ) steps were calculated using the linear trapezoidal rule after correcting for radioactivity decay. The rinsing volumes (V rin ), volumes required to get no more radioactivity, were measured in a graduated test tube. The values were compared using a Kruskall-Wallis test (p Results Despite the differences in dead-space volume, AUC adm were not significantly different (see table 1). The rinsing volumes were significantly different between the tested devices, ranging between 46.8 ± 5.7 mL and 92.2 ± 8.9 mL. Conclusion The rinsing conditions required to administer the same dose are really different between devices. The impact of good handling practice of these devices has to be assessed on the pharmacokinetic parameters. Reference Kontny NE, Boos J, Wurthwein G, et al . Minimization of the preanalytical error in pharmacokinetic analyses and therapeutic drug monitoring: focus on IV drug administration. Ther Drug Monit 2012;34:460–6 No conflict of interest. |
| Databáze: | OpenAIRE |
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