Guest-responsive supramolecular hydrogels expressing selective sol–gel transition for sulfated glycosaminoglycans
| Autor: | Hitoshi Inokawa, Kouichiro Noguchi, Naofumi Kuroda, Shun Ichi Tamaru, Yutaro Shimasaki, Seiji Shinkai, Yukie Tounoue, Masayoshi Takano |
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| Rok vydání: | 2020 |
| Předmět: |
010407 polymers
Dipeptide Polymers and Plastics Chemistry technology industry and agriculture Supramolecular chemistry Sequence (biology) macromolecular substances complex mixtures 01 natural sciences 0104 chemical sciences Glycosaminoglycan chemistry.chemical_compound Anionic addition polymerization Sulfation Chemical engineering Self-healing hydrogels Amphiphile Materials Chemistry |
| Zdroj: | Polymer Journal. 52:939-946 |
| ISSN: | 1349-0540 0032-3896 |
| Popis: | This paper describes the stimuli-responsive hydrogels constructed from bola-type amphiphiles composed of two dipeptides containing phenylalanine attached to the ends of a hydrophobic tetrathiophene. The hydrogel formation ability of the amphiphiles was affected by the N-terminal amino acid residue, which is an amphiphile-possessing phenylalanine-lysine sequence that formed a hydrogel under limited pH conditions. Gel formation occurred because of the phase transition of the gelator assembly from a granular aggregate to a fibrous architecture, in a process controlled by pH. This stimuli-responsive sol–gel transition was also accomplished by the addition of an anionic polymer, and sulfated glycosaminoglycans were successfully discriminated using the hydrogel system. A bola-type π-conjugated amphiphile containing Phe-Lys dipeptide showed a pH- and guest-induced phase transition from the granular aggregate to the fibrous architecture and formed a supramolecular hydrogel. Using this stimuli-responsiveness, the hydrogel system was successfully applied to the selective discrimination of glycosaminoglycans composed of a sulfated sugar unit. |
| Databáze: | OpenAIRE |
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