Concise total synthesis of flavone C-glycoside having potent anti-inflammatory activity

Autor:	Toshiyuki Wakimoto, Haruo Nukaya, Sachiko Kondo, Kiyoshi Tanaka, Tomoyuki Kimura, Hisashi Mihara, Kuniro Tsuji, Takumi Furuta
Rok vydání:	2004
Předmět:	Natural product Chemistry Stereochemistry medicine.drug_class Aryl Organic Chemistry Total synthesis Ring (chemistry) Biochemistry Anti-inflammatory chemistry.chemical_compound Intramolecular force Drug Discovery medicine Moiety Mitsunobu reaction
Zdroj:	Tetrahedron. 60:9375-9379
ISSN:	0040-4020
DOI:	10.1016/j.tet.2004.08.015
Popis:	The total synthesis of anti-inflammatory active flavone C-glycoside isolated from oolong tea extract is achieved. Introducing a C-glucosyl moiety to an aryl system and constructing a fused tetracyclic ring characteristic to this natural product were conducted based on the O-to-C rearrangement of sugar moiety and the successive intramolecular Mitsunobu reaction, respectively. This concise and efficient synthetic pathway is applicable to the large-scale synthesis of target flavone and for constructing a large library of related compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3e5c377cabba10fef3a1f13c4d545bc2 https://doi.org/10.1016/j.tet.2004.08.015 Zobrazit plný text záznamu Full Text from ScienceDirect