Chronic Toxicity/Oncogenicity Studies of 60 Hz Magnetic Fields in F344 Rats and B6C3F1 Mice: Final Survival, Body Weight, Clinical Observation, and Gross Pathology Data

Autor: J. Brooks Harder, John C. Findlay, Tim R. Johnson, Gary A. Boorman, Bernadette M. Ryan, James R. Gauger, David L. McCormick, Robert L. Morrissey
Rok vydání: 1999
Předmět:
Zdroj: Electricity and Magnetism in Biology and Medicine ISBN: 9781461372080
Popis: The results of a number of epidemiology studies have suggested a positive association between exposure to power frequency magnetic fields and the incidence of several types of malignancy1–3. However, other epidemiology studies of similar design have found no such relationship between magnetic field exposure and cancer risk4,5. Because the epidemiology database for magnetic field exposure and cancer risk is contradictory, it appears unlikely that definitive assessments of human risk associated with magnetic field exposure can be developed on the basis of epidemiology data alone. In cases where the epidemiology data are inconclusive, the importance of studies in experimental animal model systems increases. Well-controlled animal studies permit evaluation of the biological effects of magnetic fields in vivo under tightly controlled exposure conditions, and in the absence of potential confounding variables. The present report provides the results of the in-life component of studies that are designed to evaluate the chronic toxicity and potential oncogenicity of chronic exposure to 60 Hz magnetic fields in F344 rats and B6C3F1 mice.
Databáze: OpenAIRE