24 Ectopic Expression of GATA2 Normalizes Aberrant Myelomonocytic Differentiation Induced by Activating PTPN11 Mutations

Autor:	R J Chan, Z Yang, Cara S. Voorhorst
Rok vydání:	2006
Předmět:	Myeloid Juvenile myelomonocytic leukemia GATA2 Protein tyrosine phosphatase Biology medicine.disease PTPN11 Haematopoiesis medicine.anatomical_structure embryonic structures Pediatrics Perinatology and Child Health medicine Cancer research Ectopic expression Bone marrow
Zdroj:	Pediatric Research. 60:494-494
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-200610000-00046
Popis:	Purpose of Study: Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder characterized by overproduction of myelomonocytic cells. Activating mutations of PTPN11, which encodes the protein tyrosine phosphatase, Shp-2, are found in 35% of JMML patients. Murine bone marrow low density mononuclear cells (LDMNCs) expressing activating Shp-2 mutants preferentially undergo myelomonocytic differentiation despite being subjected to conditions that select for mast cell development (Chan et al., Blood 106, Abstract #3519, 2005). Consistently, GATA-2 expression is dramatically reduced in cells expressing activating Shp-2, suggesting that Shp-2 gain-of-function mutants alter hematopoietic lineage-specific transcription factors and thus shift myeloid differentiation toward the myelomonocytic lineage. We hypothesized that ectopic GATA2 expression would normalize the aberrant myelomonocytic differentiation induced by activating Shp-2 mutants.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3e4fd1b472b8a57a6fbf5db18a70a882 https://doi.org/10.1203/00006450-200610000-00046 Zobrazit plný text záznamu