Exploring a Multivalent Approach to α-L-Fucosidase Inhibition

Autor:	Gideon J. Davies, Ana T. Carmona, Lidia Molina, Daniel W. Wright, Inmaculada Robina, Antonio J. Moreno-Vargas, Elena Moreno-Clavijo
Rok vydání:	2013
Předmět:	chemistry.chemical_classification biology 010405 organic chemistry Chemistry Stereochemistry Glycoconjugate Organic Chemistry Imino Sugars α l fucosidase 010402 general chemistry 01 natural sciences Binding constant Epitope 0104 chemical sciences 3. Good health Enzyme Biochemistry biology.protein heterocyclic compounds Fucosidase Physical and Theoretical Chemistry
Zdroj:	European Journal of Organic Chemistry. 2013:7328-7336
ISSN:	1434-193X
Popis:	To probe the utility of a multivalent approach for fucosidase inhibition, a series of di- and tri-valent imino sugars based on L-fuco-configured 1,4-imino- and 1,4-bis(imino)-cyclitol epitopes has been synthesized and analyzed for fucosidase inhibition with the best trivalent species yielding a modest improvement in binding constant. Structural analysis of a representative pair of mono- and tri-valent imino sugars has been performed on a bacterial fucosidase, BtFuc2970. The 3D structures show binding of the imino-cyclitol in the 3E conformation, consistent with the known pathway for fucosidase action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3e4f9c35bd7b7e94ccf6bfebd6e8a91c https://doi.org/10.1002/ejoc.201300878 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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