Effects of Magnesium Sulfate Infusion Upon Plasma Prostaglandins in Preeclampsia and Preterm Labor
| Autor: | Thomas M. Gellhaus, Susan L. Sipes, Carl P. Weiner, James D. Goodspeed |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Pregnancy business.industry Magnesium Metabolite Obstetrics and Gynecology chemistry.chemical_element Prostaglandin Prostacyclin medicine.disease Preeclampsia chemistry.chemical_compound Endocrinology chemistry Internal medicine Internal Medicine medicine lipids (amino acids peptides and proteins) Prostaglandin E2 business Prospective cohort study medicine.drug |
| Zdroj: | Hypertension in Pregnancy. 13:293-302 |
| ISSN: | 1525-6065 1064-1955 |
| Popis: | Objective: Recent investigation has shown that magnesium stimulates the release of prostacyclin from confluent endothelial cell cultures. The goal of this study was to determine the effect of magnesium sulfate infusion on the peripheral concentrations of prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α) and 6-keto-prostaglandin F1α (6-keto-PGF1α the stable metabolite of prostacyclin) in women with either preeclampsia or preterm labor. We hypothesized that plasma prostacyclin concentrations would increase during magnesium sulfate infusion in women with preeclampsia to a greater extent than in women with preterm labor.Methods: Twenty-one women with preeclampsia and 14 women in preterm labor were enrolled in a prospective study following transfer to a tertiary center. Blood samples were obtained prior to initiating the magnesium sulfate infusion, immediately after a 4-g load and 2 h later during a maintenance infusion of 2 g/h.Main Outcome Measures: 6-keto-PGF1α PGE2 and PGF2α concentrations were measured a... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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