NF-κB inhibitory activities of triterpenoid glycosides from the stems of Acanthopanax senticosus (Rupr. & Maxim.) Harms
| Autor: | Pei-Ge Du, Na Li, Jia-Lin Li, Long Cui, Le Zhang, Zhen-Dong Tuo, Ya-Nan Sun |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Luciferase reporter biology Traditional medicine 010405 organic chemistry Stereochemistry Chemistry Glycoside NF-κB Plant Science Eclalbasaponin II biology.organism_classification Inhibitory postsynaptic potential 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Triterpenoid Hepg2 cells Araliaceae Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 15:210-214 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2016.01.008 |
| Popis: | Three new triterpenoid glycosides, 3 β -hydroxy-28-norolean-12-ene-16-one 3- O -β- d -glucopyranoside ( 1 ), 3 β ,17 β -dihydroxy-28-norolean-12-ene-16-one 3- O -β- d -glucopyranoside ( 2 ) and 3 β -hydroxy-olean-12-ene-16,28-lactone 3- O -β- d -glucopyranoside ( 3 ) together with eclalbasaponin II ( 4 ) were isolated from Acanthopanax senticosus (Rupr. & Maxim.) Harms. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. Inhibition of NF- κ B of these isolates was measured in HepG2 cells using a luciferase reporter system. Among the isolates, compounds 1 , 2 and 4 inhibited NF- κ B activation stimulated by TNF-α in a dose-dependent manner, with IC 50 values ranging from 8.3 ± 0.7 to 13.5 ± 1.0 μM. |
| Databáze: | OpenAIRE |
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