ChemInform Abstract: Biocatalytic Production of Glyoxylic Acid

Autor:	John E. Seip, Susan K. Fager, John E. Gavagan, Robert Dicosimo, Lawrence W. Gosser, David Leroy Anton
Rok vydání:	2010
Předmět:	biology Imine Glyoxylate cycle General Medicine Catalysis chemistry.chemical_compound chemistry Catalase Hemiaminal biology.protein Organic chemistry Formate Hydrogen peroxide Glyoxylic acid
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199334115
Popis:	The production of glyoxylic acid from glycolic (hydroxyacetic) acid has been demonstrated using the soluble enzymes glycolate oxidase and catalase as catalysts. Catalase was included as cocatalyst to decompose by product hydrogen peroxide, thus limiting peroxide-dependent formate production and glycolate oxidase deactivation. The addition to reaction mixtures of a primary amine capable of forming the hemiaminal or imine of glyoxylate resulted in an increase in the yield of glyoxylate; hemiaminal/imine mixtures of glyoxylate were not as readily oxidized to formate and carbon dioxide by hydrogen peroxide and also limited product inhibition of glycolate oxidase at high glyoxylate concentrations
Databáze:	OpenAIRE
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