Lymphoid organ specificity in the maintenance of secondary lymphoid tissues by TNF produced by B and T cells (95.26)
| Autor: | Alexei Tumanov, Sergei I Grivennikov, Andrei A Kruglov, Dmitry V Kuprash, Sergei A Nedospasov |
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| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 178:S182-S182 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.178.supp.95.26 |
| Popis: | Secondary lymphoid organs play an important role in generation of efficient immune responses. Using a genetic approach we revealed distinct contribution of TNF produced by B and T cells in homeostasis of secondary lymphoid organs. In spleen, the development of follicular dendritic cells (FDC) and B cell follicles was controlled primarily by TNF produced by B cells while TNF from T cells provided a distinct complementary signal, similarly to contributions reported earlier for the surface lymphotoxin (LT). Organized marginal zone structure was dependent on TNF from both B-, T- and other cell types. In contrast, in Peyer’s patches, the lymphoid microarchitecture was exclusively dependent on TNF produced by B cells. Furthermore, we show that TNF signals from both B and T cells acted in concert for the expression of TNF dependent genes in lymph nodes, generation of FDC and B cell follicles, and in mounting an efficient humoral immune response to thymus-dependent antigen. Finally, we found that soluble form of TNF provided by B cells was critical for the maintenance of secondary lymphoid organs. Thus, the organization of different secondary lymphoid organs is maintained by distinct contribution of TNF produced by B and T cells, on one hand, and distinct role of soluble versus membrane TNF form, on the other hand. |
| Databáze: | OpenAIRE |
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