Inhibitory Effects of Ceramide From the Seeds of Brassica napus L. on the Atopic Function via the Regulation of Human Kallikrein 5 and 7 Protease
| Autor: | Youngeun Seo, Kyung Suk Bae, Yu M. Kim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ceramide
medicine.medical_treatment Cell Plant Science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery medicine 030304 developmental biology Pharmacology Serine protease 0303 health sciences Protease integumentary system biology KLK5 General Medicine Atopic dermatitis Kallikrein medicine.disease medicine.anatomical_structure Complementary and alternative medicine chemistry Biochemistry biology.protein 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Natural Product Communications. 14:1934578X1987684 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x19876846 |
| Popis: | The stratum corneum tryptic enzyme kallikrein 5 (KLK5) is a serine protease that is involved in the cell renewal and maintenance of the skin barrier functions. The excessive activation of KLK5 causes an exacerbation of dermatoses, such as rosacea and atopic dermatitis. Brassica napus play a well-known role in the treatment of canola oil through their anti-oxidative and DNA protective properties. We aimed to investigate whether the bioactive ceramide modulate the KLK5 protease. The ceramides were evaluated using an enzymatic assay to measure the anti-KLK5 activity. Our study revealed that the ceramides modulate the KLK5 and 7 protease activity. Ceramides may affect the skin barrier and atopic function via the regulation of proteases. |
| Databáze: | OpenAIRE |
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