Neuromuscular blocking characteristics of vecuronium after tubocurarine-induced 'fade'

Autor:	M. G. F. Rorarius, Gerhard A. Baer, Arto I. E. Puura
Rok vydání:	1999
Předmět:	Pharmacology genetic structures Blocking (radio) Chemistry General Medicine Tubocurarine chloride Clinical study Double blind Nicotinic agonist Anesthesia medicine Pharmacology (medical) Fade Vecuronium bromide Acetylcholine receptor medicine.drug
Zdroj:	European Journal of Clinical Pharmacology. 55:173-176
ISSN:	1432-1041 0031-6970
DOI:	10.1007/s002280050614
Popis:	Objective: The fade in train-of-four (TOF) monitoring is considered to be due to blocking of the prejunctional nicotinic acetylcholine receptors (AchRs). During onset of the neuromuscular block (NMB) tubocurarine (TC) causes more fade in the TOF responses than vecuronium (VEC). Therefore we wanted to investigate whether onset or duration of action of VEC or TC would be improved with a priming dose of an agent with different prejunctional activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3e37704a98e53fad324835abf025946b https://doi.org/10.1007/s002280050614 Zobrazit plný text záznamu Full text from SpringerLink