Die Konstitution der Salamander-Alkaloide
| Autor: | Cl. Schöpf |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
Pharmacology
Oxazolidine biology Chemistry Stereochemistry Alkaloid Absolute configuration Cell Biology Ring (chemistry) biology.organism_classification Cellular and Molecular Neuroscience chemistry.chemical_compound Group (periodic table) Molecular Medicine Salamandra Oxygen bridge Molecular Biology Skin gland |
| Zdroj: | Experientia. 17:285-295 |
| ISSN: | 1420-9071 0014-4754 |
| Popis: | Four alkaloids have been isolated from the skin gland of the ‘Feuer- and Alpensalamander’ (Salamandra maculosa andatra Laur.). The structure, stereochemistry and absolute configuration of the principal alkaloid, samandarin, have been elucidated by chemical, optical, and X-ray-crystallographic methods. The basic structure of samandarin is derived from 5β-androstan by the insertion between C-2 and C-3 of ring A of an NH group which, along with an oxygen bridge between C-1 and C-3, constitutes an oxazolidine ring; at C16 there is aβ-hydroxyl group. By virtue of its origin and constitution samandarin occupies a unique position among alkaloids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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