Neurobehavioral Effects in Relation to Endocrine Alterations Caused by Exposure to Brominated Flame Retardants in Rats—Comparison to Polychlorinated Biphenyls
| Autor: | Joseph G. Vos, Aldert H. Piersma, Leo T.M. van der Ven, Alfons Hack, Hellmuth Lilienthal, Astrid Roth-Härer |
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| Rok vydání: | 2009 |
| Předmět: |
Hexabromocyclododecane
medicine.medical_specialty Offspring Health Toxicology and Mutagenesis Ecological Modeling Feminization (biology) Pollution Sexual dimorphism chemistry.chemical_compound Endocrinology chemistry Internal medicine Thyroid hormones medicine Endocrine system Tetrabromobisphenol A Testosterone |
| Zdroj: | Human and Ecological Risk Assessment: An International Journal. 15:76-86 |
| ISSN: | 1549-7860 1080-7039 |
| DOI: | 10.1080/10807030802615253 |
| Popis: | The widespread use of brominated flame retardants (BFRs) has led to increasing concentrations in environmental samples. Previous reports suggested endocrine activity of these compounds. Because thyroid hormones and sex steroids are known to regulate the development of the nervous system, we examined neurobehavioral and endocrine effects of gestational exposure to 2,2′4,4′,5-pentabrominated diphenyl ether (PBDE99) and lifetime exposure to tetrabromobisphenol A (TBBPA) or hexabromocyclododecane (HBCD) in rats. Treatment with PBDE99 (0, 1, or 10 mg/kg bw) reduced serum testosterone and estradiol in male offspring and affected sexual development in both sexes. Exposed males exhibited increased sweet preference, indicating feminization of this sexually dimorphic behavior. In TBBPA and HBCD experiments, a benchmark design was used with dose ranges of 0-3000 mg/kg bw/day and 0–100 mg/kg bw/day, respectively. Because thyroid hormones are critical for auditory development, brainstem auditory evoked potent... |
| Databáze: | OpenAIRE |
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