Prognostic impact of the pretreatment albumin to alkaline phosphatase ratio for nonmetastatic breast cancer patients
| Autor: | Jia-Peng Deng, Wen-Wen Zhang, Huan-Xin Lin, Zhi-Qing Long, Xin Hua, Zhen-Yu He, Shaowen Lv, Ling Guo |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry medicine.medical_treatment Lumpectomy Cancer Estrogen receptor medicine.disease Gastroenterology Radiation therapy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Oncology 030220 oncology & carcinogenesis Internal medicine medicine business Prospective cohort study Mastectomy Survival analysis |
| Zdroj: | Cancer Management and Research. 11:4809-4814 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s200759 |
| Popis: | Introduction: Albumin and alkaline phosphatase have been previously demonstrated as independent prognostic factors for various types of cancer. Here, we aimed to explore the potential value of pretreatment albumin to alkaline phosphatase ratio (AAPR) on overall survival (OS) in nonmetastatic breast cancer patients. Methods: A total of 746 nonmetastatic breast cancer patients were enrolled in this study. Receiver characteristic curve was used to analyze the AAPR threshold. Survival analysis was conducted using the Kaplan-Meier method and compared with the log-rank test. Both univariate and multivariate analyses were performed using Cox proportional hazards regression methodology. Results: The optimal cutoff value of AAPR in predicting OS in nonmetastatic breast cancer patients was 0.525. Increased pretreatment AAPR level was related to age at diagnosis (≥60 years vs 2 cm, P=0.034), estrogen receptor (positive vs negative, P=0.022), progesterone receptor (positive vs negative, P=0.025), carcino-embryonic antigen (abnormal vs normal, P=0.016), surgery (lumpectomy vs mastectomy, P=0.002), chemotherapy (yes vs no, P=0.004), radiotherapy (yes vs no, P=0.013), endocrine therapy (yes vs no, P=0.027) but not with lymph node involvement, HER-2 status or CA-153. The 5-year OS rate was 80.16% for the low AAPR group and 92.66% for the high AAPR group. Kaplan-Meier analysis indicated that patients with low-AAPR levels had shorter OS than patients with high-AAPR levels (P=0.001). N classification (P |
| Databáze: | OpenAIRE |
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