Evaluation and Study of Recrystellization on Polymorph of Dexamethasone by Using GC-MS and FT-IR Spectroscopy
| Autor: | Mohammed Yahya Hadi, Imad Hadi Hameed, Ali Kadhim Aljarah |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Health Toxicology and Mutagenesis Analytical chemistry 02 engineering and technology 021001 nanoscience & nanotechnology Toxicology 030226 pharmacology & pharmacy Pathology and Forensic Medicine law.invention Crystal 03 medical and health sciences symbols.namesake 0302 clinical medicine Fourier transform Polymorphism (materials science) law Microscopy symbols Gas chromatography–mass spectrometry Crystallization Solubility Fourier transform infrared spectroscopy 0210 nano-technology Law |
| Zdroj: | Indian Journal of Forensic Medicine & Toxicology. 13:372 |
| ISSN: | 0973-9130 0973-9122 |
| DOI: | 10.5958/0973-9130.2019.00072.0 |
| Popis: | Polymorphism is the phenomena where drug exists in more than one crystalline form. Though polymorphs are chemically identical, they exhibit different physicochemical properties like solubility which further affect the biological properties of drugs. The purpose of this work was to study the effect of solvents of different polarity and processing conditions on crystallization and physicochemical properties of Dexamethasone. The crystals were prepared from different polarity of solvents and processing conditions like deep freezing, law temperature cooling (4C°) and room temperature. The Fourier Transform Infra-Red and Microscopy studies were carried out to check for polymorphism in drug. The result indicate that crystal obtained from different solvents and processing conditions exhibited different physicochemical properties. FT-IR gave an indication of difference in the spectra. The crystals with different properties can be obtained by changing solvent polarity and processing conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|