Spongistatin synthetic studies. 1. Construction of a C(29–48) subtarget

Autor:	Qiyan Lin, Kiyoshi Nakayama, Patrick R. Verhoest, Christopher S. Brook, Noriaki Murase, Mark D. McBriar, Linghang Zhuang, Armen M. Boldi, William H. Moser, Amos B. Smith
Rok vydání:	1997
Předmět:	Antitumor activity Stereochemistry Chemistry Organic Chemistry Drug Discovery Total synthesis Nanotechnology Spongistatin Biochemistry Spongistatin 1
Zdroj:	Tetrahedron Letters. 38:8667-8670
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(97)10499-3
Popis:	In this Letter, the first in a series of three, we outline our overall strategy and describe the assembly of a C(29–48) EF-ring advanced intermediate for the total synthesis of the spongistatins, rare and structurally unique polyether macrolides with unprecedented antitumor activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3e19ca9a6277cec4b78d3a51d8c69340 https://doi.org/10.1016/s0040-4039(97)10499-3 Zobrazit plný text záznamu Full Text from ScienceDirect