Peptide Phage Display Technology Advancement and Uses in Biomedicine
| Autor: | Khushboo Panwar, Satyabrat Dutta, Richa Sarkar, Esha Sinha, Ambika Arun, Gorre Venu, Arpita Sain, Sudhir Kumar Prajapati |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | International Journal of Current Microbiology and Applied Sciences. 12:261-274 |
| ISSN: | 2319-7706 2319-7692 |
| Popis: | A potent research tool for high-throughput protein interaction screening is a combinatorial phage library. Phage display has established itself as the most widely used molecular display technology. It is possible to find peptides that can bind target molecules and control their function by screening phage- displayed random peptide libraries. B-cell and T-cell epitope mapping, selecting bioactive peptides bound to receptors or proteins, disease-specific antigen mimics, peptides bound to non-protein targets, cell- or organ-specific peptides, and developing peptide-mediated drug delivery systems are all possible uses for phage-displayed peptide libraries. For fundamental science and translational medicine, employing peptides as targets that have been discovered through phage display technology may be helpful. The most recent developments in the use of phage-displayed peptide libraries for applied biomedical sciences are outlined in this review article. |
| Databáze: | OpenAIRE |
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